Low effects on cytotoxicity against neuroblastoma cancer cell line (SK-N-SH) and free-radical scavenging activity of Stemona alkaloids

Sumet Kongkiatpaiboon, Primchanien Moongkarndi, Wandee Gritsanapan

Abstract


Stemona plants contain alkaloids with different skeletal types. They are well-characterized and are commonly used for insecticide, killing head lice, treating skin diseases, antitussive, and anticancer treatment. Eleven Stemona alkaloids of three skeletal types, protestemonine-, croomine-, and stichoneurine-type, i.e. protostemonine-type (didehydrostemofoline, stemofoline, stemocurtisine, stemocurtisinol, stemokerrine, oxystemokerrine), croomine-type (croomine), and stichoneurine-type (tuberostemonine, tuberostemonine A, tuberostemonine N, neotuberostemonine) were isolated from various Stemona roots and investigated for their cytotoxicity and free radical scavenging activity, which have not yet been reported. Cytotoxicity on neuroblastoma cancer cell (SK-N-SH) was determined by MTT assay, while free radical scavenging activity was investigated using the DPPH radical scavenging method. Protostemonine type alkaloids possessed insignificant effect on the cytotoxicity and free radical scavenging activity, while croomine and stichoneurine type alkaloids showed weak to moderate effects.

Keywords


anticancer; antioxidant; MTT assay; stemofoline; Stemona; tuberostemonine

Full Text:

PDF

Comments on this article

View all comments


This website is optimized for the last versions of Internet Explorer (V. 7 or higher) and Firefox. We therefore advise to download (or upgrade your internet browser to) IE 7 or Firefox. All rights reserved to The All Results Journals (c).


To help promote The All Results Journals:Biol (ISSN:2172-4784) you can now download our poster and display it in your library, common room, office or laboratory.